Ozge Yapar

Ozge Yapar
  • Doctoral Candidate

Contact Information

  • office Address:

    514.1 Jon M. Huntsman Hall
    3730 Walnut St.
    Philadelphia, PA 19104

Research Interests: healthcare operations management, health economics, clinical trial design, applied probability, stochastic processes

Links: CV, LinkedIn

Overview

Ozge Yapar is a sixth-year doctoral candidate in the Operations Management track. Her research focuses on healthcare operations management, specifically on the process of developing and marketing new medical treatments. She uses tools from applied probability, stochastic processes, simulation optimization, and health economics.

In a recently completed work, she addresses the spiraling costs of clinical trials by developing an adaptive trial design that considers the value of multiple correlated alternatives. Her current work analyzes pharmaceutical risk-sharing agreements which allow for post-marketing updates to the price as a function of clinical effectiveness.

Ozge earned her Bachelor of Science degree in Industrial Engineering from Bilkent University in Turkey, and she spent her third year of undergrad studying in Industrial Engineering and Operations Research Department of the University of California Berkeley as a visiting student.

 

 

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Research

  • Stephen E Chick, Noah Gans, Ozge Yapar (Work In Progress), Risk-sharing Agreements For New Medical Treatments.

    Abstract: Any estimate of a new medical treatment’s value that relies on clinical-trial data can have significant residual uncertainty. So-called post-marketing data, captured after the treatment has entered the market and is used by the general population, can augment clinical-trial data to better validate its safety, efficacy, and economic value. To better manage the risks associated with this post-trial residual uncertainty, new price updating mechanisms are under consideration around the world. We analyze these new risk-sharing arrangements.

  • Stephen E Chick, Noah Gans, Ozge Yapar (Under Revision), Bayesian Sequential Learning for Clinical Trials of Multiple Correlated Medical Interventions.

    Abstract: We integrate emerging trends intended to improve clinical trial design: design for cost-effectiveness, which ensures health-economic improvement of a new intervention over the current standard intervention; adaptive design, which dynamically adjusts the sample size and allocation of patients to different interventions; and multi-arm trial design, which compares multiple interventions simultaneously. Our goal is to identify a sequential sampling policy that dynamically decides the interventions to which patients should be allocated, as well as when to stop patient recruitment, in order to maximize the expected population-level benefit minus the cost of the trial. The literature on sequential sampling develops indices that either accommodate correlation among the mean rewards of alternatives or are based on optimal stopping times that can dynamically change as samples are taken, but not both. We develop the first tractable allocation and stopping rules whose indices capture both correlation and dynamic stopping times, and our numerical experiments demonstrate the value of considering both problem elements in the context of clinical trials.

  • Lorin M. Hitt, Ruben Lobel, Ozge Yapar (Work In Progress), Technology sharing in two-sided markets.

    Abstract: This paper investigates the drivers behind Tesla's decision to make its patents freely available to other electric car manufacturers. The two sides of this market, car owners and potential charging stations, rely on each other to increase the value of their investment. We show under what conditions subsidizing the competitors can be profitable. By sharing technology, Tesla may be able improve the charging station network and increase it's own profit from car sales.

Awards and Honors

Runner-up, Pierskalla Best Paper Award by INFORMS Health Applications Society, 2018
Wharton Risk Center Russell Ackoff Doctoral Student Fellowship Award, 2017, 2018
Wharton Doctoral Fellowship, 2013 – 2017
Bilkent University Comprehensive Scholarship, 2008 – 2013
Tekfen Foundation Scholarship, 2008 – 2012
Higher Education Student Loans and Dormitories Institution Fellowship, 2008 – 2012
Turkiye Is Bankasi “Golden Students” Grant, 2008

    Activity

    Latest Research

    Stephen E Chick, Noah Gans, Ozge Yapar (Work In Progress), Risk-sharing Agreements For New Medical Treatments.
    All Research